Great advice from Seth Godin:
http://feedproxy.google.com/~r/typepad/sethsmainblog/~3/NmXymlAkOms/simple-five-step-plan-for-just-about-everyone-and-everything.html
via Byline
The number of people you need to ask for permission keeps going down:
1. Go, make something happen.
2. Do work you're proud of.
3. Treat people with respect.
4. Make big promises and keep them.
5. Ship it out the door.
When in doubt, see #1.